In machining, we learn to live with, and work with, whatever minimum we can achieve.
My two cents as spoken by a true amateur.
When we have a manual milling machine generally the best we can do is motion in X or Y. If we need 32 degrees from X=0 we turn the part 32 degrees and then move in X. Rotary tables will do that for us for some parts.
When we need to bore a hole we use a boring tool tweaking it until it measures correctly. We have either power down feed or we turn the handle very slowing creating a smooth cut. And we lock the table to it doesn't move or get pulled away from the nut during this boring operation.
In each case we adjust the work or the direction of cut so that backlash isn't an issue. Try to do deep aggressive cuts with climb milling and you can see the cutter pull the table forward away from the driving nut by the black-lash slop. Do conventional milling and we're always loaded against the nut.
That's why threading on a lathe is never an issue from a backlash perspective because the tool is always loaded against the driving lead screw surface.
Enter CNC and the world as we knew it changes. Now with the ability to profile the path of a hole we don't bother mucking around with a boring tool. Especially if the diameter isn't super critical. But following a curved profile means the load on the lead screw changes as you follow the curve. Now backlash, taken out by the CNC software is a rapid acceleration and motion in the opposite direction meant to again put the load on the lead screw nut.
The problem is the table can still be pulled or pushing in the wrong direction and the hole is not perfectly round. Not like using a boring tool.
Then there's the issue of uneven wear on older machines. The backlash in the middle of the table is 0.021" but only 0.010" at one end and 0.012" at the other end. Unless the CAM system has the ability to profile the wear the backlash removed in the middle is correct but makes for inaccurate cuts at the end.
So
@Susquatch is correct that we learn to work with the machine and tweak as we go. But if you want to automate, in the long run, ball screws are the only way.